It is hard to express how important cleanliness is as it relates to saddle issues. Saddle sores can be uncomfortable, excruciating or end a trip in its tracks. There are two kinds of cycle tourists. Those that have had painful saddle sores , and those who will someday. These wipes seem to help tremendously in making them a lot less likely. Since utilizing them I can say I have not had a single issue where before it would happen every few years or so. Different saddles, setups, conditions and terrain also play a factor but I firmly believe these help.